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The efficacy and safety of MiGuard vs other headache nutritional supplements - A comparative study

Migraines are a neurological dysfunction and a major cause of disability. It is estimated that about 15% of the general population suffer from this disabling headache disorder. In individuals predisposed to migraine headaches, certain areas within the brain react in an exaggerated manner to a variety of triggers which initiates the cascade of events resulting in the excruciating throbbing pain of migraine headaches with associated symptoms of nausea, light and sound
sensitivity and dizziness.

Research into human brain activity reveals that migraine is a metabolic abnormality of the brain with increased oxidative stress and decreased antioxidant capacity. This abnormality is due to lower levels of certain essential nutrients which ultimately results in an energy deficiency syndrome at the mitochondrial level in the brain. Mitochondria is the powerhouse of every cell in our body. This oxidative stress predisposes the brain of migraineurs to the start of a cascade of events that culminates in an inflammatory process resulting in the throbbing pain of migraine

The most important initiating pathophysiological event is the release of a neurotransmitter called Glutamate and the activation of NMDA receptors. This event in turn initiates a process called cortical spreading depression or CSD. Cortical spreading depression basically is a slow wave of brain activity (depolarization) that travels across the surface of the brain and ultimately results in the trigeminal neuronal release of CGRP and substance P. The release of these neurochemicals is
responsible for the neurogenic vasodilation and mast cell degranulation which causes increased vascular permeability (leaky blood vessels), neurogenic inflammation and sensitization of then meningeal nerve fibers during an attack of migraine.

This nociceptive or painful information is then transmitted along the trigeminal nerve to the trigeminal nucleus in the brain stem and from there to the thalamic nuclei and the cerebral cortex where migraine pain is perceived. With its unique formulation and with supplementing the brain with the essential nutrients that it may be lacking, MiGuard may not only decrease the sensitivity of the brain to the migraine
triggers but it also may disrupt all or most of the cascade of events that is responsible for the full blown headache of the migraines.

Watch this video below to learn more on how migraine affects your brain

Migraine is a neurological disorder and a major cause of disability, affecting 15% of the general population. Recent evidence supports that migraine is a metabolic disorder and a nutritional deficiency syndrome of  the brain. Nutritional supplementation has been shown to be very beneficial in managing this primary headache disorder. The study objectives were to compare the efficacy and safety of MiGuard with other popular nutritional  supplements used to manage migraine headaches.  

Study design: Retrospective comparative analytic study based on patient interviews and feedback  

Subjects: 100 patients between ages of 18 to 50, suffering from 8 or more migraine headache attacks with or without  aura receiving MiGuard, which contains a proprietary formulation of Alpha Lipoic Acid (ALA), Magnesium, Ginger,  Feverfew, Coenzyme Q-10 and Riboflavin (Arm 1), vs other nutritional supplements containing a combination of  Magnesium, Coenzyme Q10, Riboflavin, and Butterbur (Arm2).  

Methods: Review of outcomes in regards to safety and the decrease in frequency of migraine headaches after an  uninterupted use of the supplements in (Arm 1) and (Arm 2) for more than 90 days based on the manufacturers  recommendations:  

No severe adverse effects were reported by patients in either groups except for moderate increased frequency of  bowel movements in (Arm 2) when 4 patients had to discontinue the use of the supplement. This was attributed to the  high concentration of Magnesium in the (Arm 2) supplements. As expected both groups reported a neon yellow  discoloration of the urine due to Riboflavin which is of no consequence.  

After 90 days, the reported decrease in headache attacks was 74% in (Arm 1) as opposed to 42% in (Arm 2) of the  study which was statistically significant.  

Results: Recent evidence supports that migraine is a nutritional deficiency syndrome of the brain and causes a sterile  neuroinflammatory reaction in the trigemino-vascular complex. It has been demonstrated that more than 90% of  patients suffering from high frequency migraine headaches have significantly deficient levels of ALA in their blood  stream. MiGuard has a unique proprietary formulation to include ALA in conjunction with the other ingredients and  provides the brain with anti-inflammatory, anti-Glutaminergic, anti-CGRP, anti-oxidant and neurostabizing  properties. MiGuard provides the most physiologic and synergistic nutritional support for healthy brain function. Due  to safety concerns Butterbur was not included in the formulation of MiGuard.  

As Migraine could be decades long neurological dysfunction, the safety of nutritional supplementation especially if  containing Butterbur must be brought into question. Long term exposure to to Butterbur has been associated with  severe hepatic injury and liver failure. This side effect seems to be due to Pyrrolizidine Alkaloids (PA) present in some  Butterbur products. Long term safety of PA free Butterbur is still not established.  

Conclusion: Based on this retrospective study, MiGuard seems to be safe and highly effective in decreasing  frequency of migraine headaches with or without aura.  


Benjamin Taimoorazy, MD FAHS  

Beverly Hills Migraine & Pain Management Institute  

Beverly Hills, CA 90210  

Guardian Headache & Pain management Institute  

Bloomington IL 61704  

Faculty of medicine, University of Illinois, Urbana/Champagne 

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